In today’s fast-paced world, as acne continues to victimize millions of people around the world, a variety of prescribed acne medicine is available. There are some topical and systemic prescription acne medicines these days that play a vital role in acne treatment. It is necessary to note, in the first place, that topical prescription acne medicines are generally prescribed for mild to severe acne, while the systemic therapy is needed to treat severe acne and may be used for moderate cases.